Dermatology

Dermatologist-Approved Drugstore Skincare Swaps That Actually Work

Building a healthy skincare routine doesn’t have to mean spending a fortune. The truth is, many affordable products from the drugstore can deliver excellent results when used consistently, and with the right guidance.

Our dermatology team at Clinic 5C put together this list of dermatologist-approved drugstore skincare swaps alongside a few of our favorite medical-grade products for those who want to take results even further.

Our Clinic 5C favorites can be found in-clinic, while our drugstore skincare recommendations can be found at many major retailers like CVS, Ulta, Target, and Amazon.

1. Daily SPF Moisturizers

"If you only commit to one product, make it sunscreen." Desiree Barclift, PA-C says.

Daily SPF is the single most effective way to prevent premature aging and reduce your risk of skin cancer. UVA rays penetrate deep into the skin, breaking down collagen and elastin over time, which leads to wrinkles, sagging, and uneven texture.

Clinic 5C Sunscreen Favorites:

SkinBetter Science Sunbetter Advanced Mineral Sunscreen (Tinted) – Lightweight, elegant protection that doubles as a cosmetic tint.
EltaMD UV AOX Elements SPF 50 – A gentle mineral-based formula ideal for sensitive skin.

Drugstore Skincare Swaps:

CeraVe AM Facial Moisturizing Lotion with SPF 30 – A simple, everyday favorite with added ceramides for hydration.
La Roche-Posay Anthelios UV Daily SPF 50 – Not mineral, but extremely lightweight and perfect for everyday use (even for men who typically skip sunscreen).

2. Daily Antioxidant Serum (Vitamin C)

Antioxidants like Vitamin C help defend your skin from free radicals and oxidative stress caused by UV rays and pollution.

They can brighten the complexion and support collagen production, making them a powerful addition to any morning routine.

Clinic 5C Favorites:

SkinBetter Science Alto Advanced Defense and Repair Serum
SkinCeuticals C E Ferulic – A proven formula often recommended by dermatologists worldwide.

Drugstore Skincare Swaps:

CeraVe Vitamin C Serum – Gentle and fragrance-free.
La Roche-Posay Vitamin C12 Serum – A smooth, brightening option for most skin types.
e.l.f. Bright Icon Vitamin C Serum – The most affordable pick, and surprisingly effective for the price.

3. Gentle Daily Cleansers

A cleanser should remove impurities without over-drying your skin.

Unlike harsh scrubs that can lead to irritation and damage to the protective barrier, here are some gentle swaps instead.

Clinic 5C Favorite:

SkinCeuticals Soothing Cleanser Foam – Calms the skin while cleansing thoroughly.

Drugstore Skincare Swaps:

CeraVe Hydrating or Foaming Facial Cleanser – Non-stripping and balanced for all skin types.
La Roche-Posay Toleriane Hydrating Gentle Cleanser – Ideal for dry or sensitive skin.

For Acne-Prone Skin:
Look for cleansers containing benzoyl peroxide or salicylic acid to reduce breakouts and inflammation.

4. Nightly Retinoid

Retinoids help increase cell turnover, reduce fine lines, and improve texture.

It’s one of the most studied and effective ingredients for both acne and anti-aging.

Clinic 5C Favorite:

SkinBetter Science AlphaRet Overnight Cream – A next-level retinoid blend that’s gentle yet powerful.

Drugstore Skincare Swaps:

Adapalene 0.1% Gel (generic) – Prescription strength, now available over the counter.
La Roche-Posay Effaclar Adapalene Gel 0.1% – A refined texture for easy use.
CeraVe Skin Renewing Retinol Serum – A mild option for beginners.

5. Nighttime Moisturizers

A good evening moisturizer helps counteract dryness and sensitivity from retinoids.

Look for ingredients like hyaluronic acid, ceramides, and niacinamide to support your skin barrier and lock-in moisture overnight.

Dermatologist-Approved Picks:

Vanicream Daily Facial Moisturizer with Hyaluronic Acid – Gentle, fragrance-free, and ideal for sensitive skin.
CeraVe PM Facial Moisturizing Lotion – A classic lightweight hydrator for nightly use.

The Bottom Line

Overall, the best skincare routine is one you can maintain.

Consistency matters more than price, and today’s drugstore skincare swaps can go a long way toward improving skin health when paired with smart daily habits like sunscreen use and gentle cleansing.

For those who want to elevate results, our in-clinic lines (SkinBetter Science, EltaMD, and SkinCeuticals) offer advanced formulations with clinical-grade ingredients. You are able to purchase them in-clinic after your routine appointments.

If you’d like help customizing your routine, our dermatology team can guide you toward the right balance of professional and over-the-counter products for your skin type and goals - get in touch with us today!